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Technická 5
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Česká platforma antibiotické rezistence Vás zve na seminář:

 

Antibiotická rezistence v ČR: Jak společně zastavit nezastavitelné

seminář o medicíně, mikrobiologii a životním prostředí pro širší odbornou veřejnost se díky projektu REPARES konal 17.5. 2023 od 9:30 ve Smetanově sále Autoklubu ČR (Opletalova 29, Praha 1) 

Boj s antibiotickou rezistencí vyžaduje multidisciplinární týmy expertů z oblasti humánní a veterinární medicíny, mikrobiologie a environmentální technologie. Cílem vznikající České platformy antibiotické rezistence (CZEPAR) je sdružovat odborníky z akademické sféry, praktické medicíny, firemního sektoru a státní správy.

Chcete se dozvědět více? Zaregistrujte se na seminář CZEPAR o možnostech mezioborového řešení problematiky antibiotické rezistence v České republice.

 

Program semináře 

09:00 – 09:30 

Registrace účastníků

09:30 – 09:40

Úvod semináře

 - Ing. Dana Kok, Ph.D. / Prof. Ing. Jan Bartáček, Ph.D. (Vysoká škola chemicko-technologická v Praze)

09:40 – 09:55

Fenomén antibiotická rezistence

 - doc. MUDr. Helena Žemličková, Ph.D. (Státní zdravotní ústav)

10:00 – 10:15

Klinické zkušenosti s managementem infekcí způsobených gramnegativními bakteriemi se závažnou rezistencí k antibiotikům

 - MUDr. Jan Závora a Ing. Gabriela Kroneislová (Všeobecné fakultní nemocnice a 1. Lékařská fakulta Univerzity Karlovy)

10:20 – 10:35

Meticilin rezistentní Staphylococcus aureus v českých a slovenských nemocnicích a komunitě

 - Mgr. Jan Tkadlec, Ph.D. (Fakultní nemocnice Motol, 2. Lékařská fakulta UK)

10:40 – 11:00

občerstvení

11:00 – 11:20

Problematika antibiotické rezistence z pohledu veterinární medicíny

 - MVDr. Tomáš Černý (Státní veterinární ústav Praha)

11:25 – 11:45

Interakce mezi společností a životním prostředím – One Health koncept

 - doc. RNDr. Monika Dolejská, Ph.D. (Ústav laboratorní medicíny,

Fakultní nemocnice Brno, CEITEC)

11:50 – 12:10

Antibiotická rezistence očima Evropské unie

 - MUDr. Pavel Březovský, MBA (Státní zdravotní ústav)

12:10 – 13:00

oběd

13:10 – 14:30

Panelová diskuse (1 moderátor, 3 – 4 panelisté)

14:30 – 14:50

občerstvení

14:50 – 15:05

Antibiotická rezistence na čistírnách odpadních vod

 - Ing. Petra Moťková, Ph.D. a Ing. Iveta Brožková, Ph.D. (Univerzita Pardubice)

15:10 – 15:25

Antibiotická rezistence ve vodách, kalech a dopady na životní prostředí i lidské zdraví

 - Ing. Sabina Purkrtová, Ph.D. (Vysoká škola chemicko-technologická v Praze)

15:30 – 15:45

Česká platforma antibiotické rezistence: Jak společně zastavit nezastavitelné

 - Ing. Dana Kok, Ph.D. / Prof. Ing. Jan Bartáček, Ph.D. (Vysoká škola chemicko-technologická v Praze)

15:45 – 15:55

Shrnutí semináře a pozvání na závěrečnou diskusi u občerstvení

16:00 – ??:??

Závěrečný networking

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REPARES (Research Platform on Antibiotic Resistance Spread through Wastewater Treatment Plants), a consortium of leading academic, industry, and policymakers knowledgeable in the Antibiotic Resistance (AR) subject, is geared towards contributing excellence in research on the spread of AR in wastewater treatment plants (WWTPs).

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 ◳ 1 (png) → (ořez 215*215px)

 

The REPARES Team, mostly made up of academic leaders from top universities across Europe, has established strong cooperation with leading European innovators and internationally renowned experts in the water-related antibiotic resistance field.

 

  • UCT will coordinate and work with AR experts to provide methodologies and development of the REPARES platform
  • UCP will leverage its expert leadership in wastewater-mediated antibiotic resistance.
  • TUDelft will deliver methods to apply for international projects successfully.
  • Wetsus will propel cooperation with the non-academic sector.
  • AAU will integrate the REPARES database within the world-accepted MiDAS.
  • UW will do the bioinformatics and the validation of qPCR primers.

 

Background

Antibiotics were developed in 1940 solely for the treatment of infections in humans and animals. Over the years, diseases considered deadly were considered non-issues due to the effectiveness of these medicines. Regrettably, the benefits of antibiotics have been hampered by the development of resistance to antibiotics by bacteria. In recent times certain antibiotics used to eradicate some bacteria have become inactive. Antibiotic resistance (AR) has become prevalent, spreading primarily in populations and the environment. Thus, the development and proliferation of antibiotic resistance are classified among major global threats by the World Health Organization ( ). In addition, the European Centre for Disease Prevention and Control described the colossal effect of AR on the human population resulting in approximately 25,000 deaths per annum, costing the health care sector over  1.5 billion every year.

Proper sanitation of the water cycle is essential to sustain environmental and human health. The role of wastewater treatment plants (WWTPs) and their microbiomes as putative hotspots for the proliferation of antibiotic resistance has questioned how effective these treatment systems are. Increasingly rising public, stakeholders, and governmental perception on this issue has highlighted the need for new quality criteria and installation upgrades.

Despite the gravity of the AR problem, in the wastewater sector, methodological biases have been the sole limiting factor on adequately monitoring the emission, fate, and possible amplification or removal of antibiotic-resistant bacteria (ARB) and antibiotic resistance genes (ARGs) across WWTPs. Indeed, there is an urgent need to develop standardized methods and a well-curated database for accurate identification, characterization, and quantification of antibiotic resistance in such complex water matrices as wastewater. These issues are what REPARES aims to solve during the project period.

 ◳ 2 (png) → (ořez 215*215px)REPARES Goals

REPARES aims at advancing the European community’s know-how on antibiotic resistance across sanitation waterways, which in the future will bring society closer to achieving the Sustainable Development Goal of the United Nations. REPARES will act as an important vector to disseminate information on antimicrobial resistance spread within European WWTPs beyond science and technology to reach the academic and non-academic communities utilizing open events, popularization publications, and operation of the REPARES web platform.

Duration of Project

1 October 2019 - 30 September 2022

The relevance of research on antibiotic resistance

  • Antibiotics are one of the common contaminants in wastewater.
  • The increased bacterial antibiotic resistance stems from the spread of antibiotic-resistant bacteria and the transfer of resistance genes.
  • Antibiotic resistance can be acquired through random gene mutations and/or by horizontal gene transfer.
  • The World Health Organization qualified antibiotic resistance development as a significant global threat to society.

REPARES Objectives ◳ Untitled design (jpg) → (originál)

  • The increasing level of UCT’s scientific excellence
  • Improving scientific profiles of UCT’s researchers
  • Increasing UCT’s ability to apply for international projects successfully
  • Fostering cooperation with the non-academic sector
  • Advancing European community’s know-how on antibiotic resistance occurrence and spread in Europe
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In total 49 members (except for REPARES members) joined the REPARES platform. The members are in total from 20 countries all around the world. The highest amount of people is from the Czech Republic, however, there are also more people from Belgium, Columbia, Denmark, France, the Netherlands, Poland, the United States of America, and the South African Republic. We also have one member from Argentina, Canada, Egypt, Great Britain, Ireland, Italy, Mexico, Spain, Sweden, Switzerland, and Norway.

Most of the members are from universities (29 members), companies (8 members), policymakers (4 members), institutions (3), and laboratories (2 members). There is also one member from the platform and 2 undefined members.

 ◳ MapChart_Map (png) → (originál)

Distribution of REPARES members across the world

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Webpage under serious reconstruction! Be back soon!

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Webpage under serious reconstruction! Be back soon!

Newsletter 1 (May 2020)

Newsletter 2 (November 2020)

Newsletter 3 (March 2021)

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What happens with antibiotic leftovers that you put in the garbage? And what about the antibiotics that humans and animals are taking?  

Are there properly treated? Did they disappear without a problem? Not so much. Have a look at our graphics and learn what is the fate of antibiotics in the environment. If you want to know more, have a look at our Antibiotic resistance page.

 ◳ REPARES graphical abstract (jpg) → (originál)

 

Do you think that when you get rid of bacteria in the toilet, it’s over?

Wrong! You send them to a party to make new friends, share experiences, food, and genetic information. Let's see together what is going on at such a party and how it relates to us. Can antibiotics stop all the bacteria? Certainly not all of them, the unstoppable are called superbugs.

Let's see what are these antibiotic-resistant bacteria and what can we do to avoid them...

 

Let's listen to the members of REPARES led by Jan Bartacek talk passionately about why we need to study antibiotic resistance in wastewater treatment plants and the environment. Members from all over Europe talk about how they view antibiotic resistance and what their research in conjunction with REPARES aims to achieve...

Research Platform on Antibiotic REsistance Spread through Wastewater Treatment Plants (REPARES) is an H2020 project dealing with one of the largest threats to human health globally - antibiotic resistance. REPARES brings together both academic and non-academic subjects in combating antibiotic resistance spread in the environment. If your project or research touches on this topic, join REPARES at https://repares.vscht.cz/ and help tackle antibiotic resistance together...

Immerse yourself in the captivating video by the REPARES Project, as it unveils the intricate web of antibiotic resistance propagation in wastewater treatment plants. Delve into the profound implications of this worldwide health crisis and witness the unwavering determination in the fight against it...

 

...

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Research platform on antibiotic resistance spread through wastewater treatment plants

 ◳ Bartacek 5 (jpg) → (ořez 215*215px)

 

Jan Bartáček

Project Coordinator, UCT Prague

repares@vscht.cz

 ◳ Pokorna Lucie 6 (jpg) → (ořez 215*215px)

 

Lucie Pokorná

Project Administration, Webmaster

repares@vscht.cz

 ◳ Ojobe Lois (jpg) → (ořez 215*215px)

 

Bukola Lois Ojobe

Webmaster

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David W. (originál)

Assistant Professor David Weissbrodt received his Ph.D. in environmental biotechnology & molecular biology from EPFL with doctoral education at ETH Zürich, Switzerland. He was a postdoctoral scientist at ETH Zürich and Eawag – Swiss Federal Institute of Aquatic Science and Technology, prior to joining Aalborg University, Denmark, and the TU Delft as Swiss NSF Fellow. Since 2016 he is a faculty member and principal investigator at the TU Delft Department of Biotechnology. He teaches in both the Life Science & Technology and Civil Engineering & Geosciences programs. He received one of the best teaching awards of the Environmental Engineering track two years (2017/18, 2018/19) in a row. He is a member of the management committees of the specialist groups on Environmental Engineering Education (E3) and Microbial Ecology & Water Engineering (MEWE) of the International Water Association (IWA). His research was internationally rewarded with the 2019 inaugural IWA MEWE Early Career Researcher Award at the University of Hiroshima, Japan.

The Weissbrodt Group for Environmental Life Science Engineering elucidates microbiome science and engineering. It owns a multidisciplinary competence in “process ecogenomics” that spans from eco-design and biorefinery to wastewater-based epidemiology and biosafety via environmental systems biology and chemical ecology.

DW group (originál)

We target (i) microbiomes from flocs, biofilms, and granules for water and resource recovery; (ii) microbial and metabolic drivers of exopolymerizations; (iii) microbial niche differentiation in mixed-culture fermentation; (iv) light-driven metabolic versatility of phototrophs; and (v) transfer of mobile xenogenic elements across water systems and their microbial communities.

We are active in two key national projects on antimicrobial resistance (AMR). Together with the Institute of Biology Leiden, we lead research on the transmission of AMR genes and engineered DNA from transgenic biosystems into nature (“TARGETBIO”; Ph.D. candidate David Calderón Franco) within the Biotechnology & Safety Program of the Dutch Research Council. On collaboration with Wetsus (Ph.D. candidate Rebeca Pallarés Vega), we investigate the mechanisms of the spread of AMR in biological wastewater treatment.

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